Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia

  title={Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia},
  author={Daniel Farr{\'e} and Ana Patricia Mu{\~n}oz and E. {\'A}lvarez Moreno and Irene Reyes-Resina and J{\'u}lia Canet-Pons and Iria G. Dopeso-Reyes and Alberto J. Rico and Carme Llu{\'i}s and Josefa Mallol and Gemma Navarro and Enric I. Canela and Antonio Cortes and Jose L Labandeira-Garcia and Vicent Casad{\'o} and Jos{\'e} L Lanciego and Rafael Franco},
  journal={Molecular Neurobiology},
Radioligand binding assays to rat striatal dopamine D1 receptors showed that brain lateralization of the dopaminergic system were not due to changes in expression but in agonist affinity. D1 receptor-mediated striatal imbalance resulted from a significantly higher agonist affinity in the left striatum. D1 receptors heteromerize with dopamine D3 receptors, which are considered therapeutic targets for dyskinesia in parkinsonian patients. Expression of both D3 and D1–D3 receptor heteromers were… CONTINUE READING
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