Strong sonic hedgehog signaling in the mouse ventral spinal cord is not required for oligodendrocyte precursor cell (OPC) generation but is necessary for correct timing of its generation.

Abstract

In the mouse neural tube, sonic hedgehog (Shh) secreted from the floor plate (FP) and the notochord (NC) regulates ventral patterning of the neural tube, and later is essential for the generation of oligodendrocyte precursor cells (OPCs). During early development, the NC is adjacent to the neural tube and induces ventral domains in it, including the FP. In… (More)
DOI: 10.1016/j.neuint.2017.11.003

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Cite this paper

@article{Hashimoto2017StrongSH, title={Strong sonic hedgehog signaling in the mouse ventral spinal cord is not required for oligodendrocyte precursor cell (OPC) generation but is necessary for correct timing of its generation.}, author={Hirokazu Hashimoto and Wen Qi Jiang and Takeshi Yoshimura and Kyeong-Hye Moon and Jinwoong Bok and Kazuhiro Ikenaka}, journal={Neurochemistry international}, year={2017} }