Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection.

@article{Leeuwen2006StrongSO,
  title={Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection.},
  author={Ester M. M. van Leeuwen and Ester B. M. Remmerswaal and Mirjam H M Heemskerk and Ineke R J M Ten Berge and Ren{\'e} van Lier},
  journal={Blood},
  year={2006},
  volume={108 9},
  pages={3121-7}
}
To obtain insight into human CD4+ T cell differentiation and selection in vivo, we longitudinally studied cytomegalovirus (CMV)-specific CD4+ T cells after primary infection. Early in infection, CMV-specific CD4+ T cells have the appearance of interferon gamma (IFNgamma)-producing T-helper 1 (TH1) type cells, whereas during latency a large population of CMV-specific CD4+ CD28- T cells emerges with immediate cytotoxic capacity. We demonstrate that CD4+ CD28- T cells could lyse CMV antigen… CONTINUE READING