Strong positive selection and habitat-specific amino acid substitution patterns in MHC from an estuarine fish under intense pollution stress.

@article{Cohen2002StrongPS,
  title={Strong positive selection and habitat-specific amino acid substitution patterns in MHC from an estuarine fish under intense pollution stress.},
  author={Sarah Cohen},
  journal={Molecular biology and evolution},
  year={2002},
  volume={19 11},
  pages={1870-80}
}
  • Sarah Cohen
  • Published 2002 in Molecular biology and evolution
Population-level studies using the major histocompatibility complex (Mhc) have linked specific alleles with specific diseases, but data requirements are high and the power to detect disease association is low. A novel use of Mhc population surveys involves mapping allelic substitutions onto the inferred structural molecular model to show functional differentiation related to local selective pressures. In the estuarine fish Fundulus heteroclitus, populations experiencing strong differences in… CONTINUE READING
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References

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Showing 1-10 of 14 references

Sequence diversity of Mhc genes in lake whitefish

  • C. LARGIADER
  • Fishes of the Gulf of Maine
  • 2001

Fine - scale differentiation between contaminant - tolerant and contaminant - sensitive fish populations

  • S. CHRIST
  • Immunol . Rev .
  • 2000

Population size and genetic diversity in sand lizards ( Lacerta agilis ) and adders ( Vipera berus )

  • M. OLSSON, H. WITTZELL, B. STILLE, R. SHINE, S. ANDERSSON
  • Fundam . Appl . Toxicol .
  • 2000

Adaptations of wild populations of the estuarine fish Fundulus heteroclitus to persistent environmental contaminants

  • M. HUBER
  • Mar . Biol .
  • 1999

Genetic variation of major histocompatibility complex and microsatellite loci : a comparison in bighorn sheep

  • P. HEDRICK
  • J . Fish Biol .
  • 1997

Effect of in vivo pentachlorophenol exposure on Fundulus heteroclitus phagox - ytes : modulation of bactericidal activity

  • K. CROOKS
  • Dis . Aquat . Org .
  • 1996

Genetic variation and the immune response in natural populations of pocket gophers

  • F. FIGUEROA, C. O’HUIGIN, D. REZNICK
  • Conserv . Biol .
  • 1996

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