Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection.

@article{Sengupta2011StrongHE,
  title={Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection.},
  author={Devi Sengupta and Ravi Tandon and Raphaella G S Vieira and Lishomwa C. Ndhlovu and Rachel Lown-Hecht and Christopher Edward Ormsby and Liyen Loh and R. Brad Jones and Keith Garrison and Jeffrey N Martin and Vanessa A. York and Gerald Spotts and Gustavo Reyes-Ter{\'a}n and Mario Ostrowski and Frederick M. Hecht and Steven G. Deeks and Douglas F Nixon},
  journal={Journal of virology},
  year={2011},
  volume={85 14},
  pages={6977-85}
}
Eight percent of the human genome is composed of human endogenous retroviruses (HERVs), which are thought to be inactive remnants of ancient infections. Previously, we showed that individuals with early HIV-1 infection have stronger anti-HERV T cell responses than uninfected controls. In this study, we investigated whether these responses persist in chronic HIV-1 infection and whether they have a role in the control of HIV-1. Peripheral blood mononuclear cells (PBMCs) from 88 subjects diagnosed… CONTINUE READING
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