Strong hepatitis C virus (HCV)-specific cell-mediated immune responses in the absence of viremia or antibodies among uninfected siblings of HCV chronically infected children.

@article{Hashem2011StrongHC,
  title={Strong hepatitis C virus (HCV)-specific cell-mediated immune responses in the absence of viremia or antibodies among uninfected siblings of HCV chronically infected children.},
  author={Mohamed Hashem and Hanaa M El-karaksy and Mohamed Tarek M. Shata and Maha Sobhy and Heba M. Helmy and Suzan El-Naghi and Gehan F. Galal and Zainab Z Ali and Gamal Esmat and Sayed F Abdelwahab and G. Thomas Strickland and Samer S. El-Kamary},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={203 6},
  pages={854-61}
}
BACKGROUND Cell-mediated immune (CMI) responses to hepatitis C virus (HCV) antigens in adults without seroconversion or viremia are biomarkers for prior transient infection. We investigated HCV-specific CMI responses in seronegative children living with HCV-infected siblings. METHODS Children 3-18 years of age living with HCV-infected siblings were screened for HCV antibodies and HCV RNA. Peripheral blood mononuclear cells (PBMCs) were evaluated for HCV-specific CMI responses by interferon… CONTINUE READING

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