Strong genetic evidence for association of TOR1A/TOR1B with idiopathic dystonia.


Recently, association of a TOR1A(DYT1)/TOR1B risk haplotype with common forms of idiopathic dystonia has been reported in the Icelandic population. Here we report a strong association of two single nucleotide polymorphisms within or in close proximity to the TOR1A 3'UTR, with the lowest p value being 0.000008, in a larger cohort of German and Austrian patients with predominantly focal sporadic dystonia.


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@article{Kamm2006StrongGE, title={Strong genetic evidence for association of TOR1A/TOR1B with idiopathic dystonia.}, author={Christoph Kamm and Friedrich Asmus and J M{\"{u}ller and Pierre Mayer and Meera Sharma and Ulf J Muller and Stefan Beckert and Rainer Ehling and Thomas Illig and H. Erich Wichmann and Werner Poewe and Juliane Centeno M{\"{u}ller and Theo Gasser}, journal={Neurology}, year={2006}, volume={67 10}, pages={1857-9} }