Strong founder effects in BRCA1 mutation carrier breast cancer patients from Latvia

@article{Cskay1999StrongFE,
  title={Strong founder effects in BRCA1 mutation carrier breast cancer patients from Latvia},
  author={B{\'e}la Cs{\'o}kay and Laima Tihomirova and Aivars Stengrēvics and Olga Siņicka and Edith Ol{\'a}h},
  journal={Human Mutation},
  year={1999},
  volume={14}
}
Germ‐line mutations of the BRCA1 gene account for approximately half of the cases of hereditary breast/ovarian cancers. We have screened index patients from 15 breast cancer families and 8 sporadic breast cancer patients from Latvia for mutations in all coding exons of the BRCA1 gene, using combined Heteroduplex Analysis/SSCP followed by direct sequencing of the variants. BRCA1 germ‐line mutations proved to be frequent in Latvian breast cancer patients, also in moderate‐risk families and… 
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