Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease

@article{Hida2006StrongEO,
  title={Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease},
  author={Yasutoshi Hida and Yoshiaki Kubo and Kazutoshi Murao and Seiji Arase},
  journal={Archives of Dermatological Research},
  year={2006},
  volume={299},
  pages={103-106}
}
The class III histone deacetylase (HDAC), SIRT1, is a mammalian homologue of the Saccharomyces cerevisiae chromatin-silencing factor Sir2 that regulates longevity. SIRT1 regulates cell survival via deacetylation of p53 and forkhead transcription factors, and overexpression of SIRT1 is reported to be essential for cell growth and survival in some kinds of cancer. To elucidate the role of SIRT1 in human skin carcinogenesis, we have examined SIRT1 protein expression in 20 cases each of squamous… CONTINUE READING

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