Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS).

@article{Huang2006StrongEC,
  title={Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS).},
  author={Ronghua Huang and Eresha Mendis and Niranjan Rajapakse and Se-kwon Kim},
  journal={Life sciences},
  year={2006},
  volume={78 20},
  pages={2399-408}
}
Even though several studies report the importance of chitosan derivatives for their anticancer activity, no clear information is available to describe the relationship between their charge properties and observed activities. In this research, differently charged chitooligosaccharide (COS) derivatives were synthesized and their anticancer activities were studied using three cancer cell lines, HeLa, Hep3B and SW480. Neutral red and MTT cell viability studies revealed that, highly charged COS… CONTINUE READING