Strong diversifying selection on domains of the Plasmodium falciparum apical membrane antigen 1 gene.

Abstract

The surface-accessible ectodomain region of the Plasmodium falciparum apical membrane antigen 1 (AMA1) is a malaria vaccine candidate. The amino acid sequence may be under selection from naturally acquired immune responses, and previous analyses with a small number of allele sequences indicate a non-neutral pattern of nucleotide variation. To investigate… (More)

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@article{Polley2001StrongDS, title={Strong diversifying selection on domains of the Plasmodium falciparum apical membrane antigen 1 gene.}, author={S. D. Polley and Declan Conway}, journal={Genetics}, year={2001}, volume={158 4}, pages={1505-12} }