Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1.

@article{Deeks2004StrongCI,
  title={Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1.},
  author={Steven G. Deeks and Jeffrey N Martin and Elizabeth Sinclair and Jeff R. Harris and Torsten B Neilands and Holden T. Maecker and Elilta Hagos and Terri Wrin and Christos J. Petropoulos and Barry M. Bredt and Joseph M McCune},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={189 2},
  pages={312-21}
}
Antiretroviral (ARV)-treated patients often maintain low to moderate levels of viremia, despite the emergence of drug-resistant human immunodeficiency virus (HIV). We studied host and viral factors that may contribute to the control of viral replication in a cohort of 189 adults. Among ARV-treated patients with detectable viremia, there was a bell-shaped relationship between Gag-specific CD4+ T cell responses and viremia, with the highest cellular immune responses observed in patients with… CONTINUE READING

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