Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype

@article{Kraemer2007StrongAO,
  title={Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype},
  author={Ursula Kraemer and Thomas Illig and T. Grune and Jean Krutmann and Charlotte Esser},
  journal={Genes and Immunity},
  year={2007},
  volume={8},
  pages={513-517}
}
Psoriasis, a skin disease with autoimmune features, can be triggered and exacerbated by genetic and environmental factors. Chemicals can break tolerance to self-antigens by interfering with antigen processing and presentation; therefore, proteins involved in antigen processing may affect susceptibility. We test here whether variants of immunoproteasome subunits LMP2 and LMP7, or antigen peptide transport proteins TAP1 (transporters associated with antigen presentation) and TAP2 are associated… CONTINUE READING

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