Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.

@article{Li2011StrongAO,
  title={Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.},
  author={Dawei Li and Hongyu Zhao and Joel Gelernter},
  journal={Biological psychiatry},
  year={2011},
  volume={70 6},
  pages={504-12}
}
BACKGROUND The alcohol dehydrogenase 1B gene (ADH1B) is hypothesized to affect predisposition to alcohol dependence (AD) and abuse. A variant of the ADH1B gene (rs1229984 or Arg48His; previously referred to as Arg [*1] and His [*1]) has been reported to be associated with reduced rates of alcohol and drug dependence. Different studies have produced inconclusive results regarding association between rs1229984 (or rs2066702) and substance dependence. METHODS Using the cumulative association… CONTINUE READING