Strong association of interleukin-6 and lipopolysaccharide-binding protein with severity of adverse reactions after diethylcarbamazine treatment of microfilaremic patients.

@article{Haarbrink2000StrongAO,
  title={Strong association of interleukin-6 and lipopolysaccharide-binding protein with severity of adverse reactions after diethylcarbamazine treatment of microfilaremic patients.},
  author={M Haarbrink and Giso Abadi and Wim A. Buurman and Mieke A. Dentener and A J Terhell and Maria Yazdanbakhsh},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={182 2},
  pages={564-9}
}
To assess the involvement of inflammatory mediators in the development of adverse reactions in filarial patients undergoing treatment, 29 microfilaremic subjects were treated with diethylcarbamazine (DEC). Before and at serial time points after initiation of treatment, plasma levels of inflammatory mediators and DEC were measured, and adverse reactions were recorded. Patients experienced no or mild, moderate, or severe adverse reactions. Increasing pretreatment microfilarial counts were… CONTINUE READING