Strong-arming immune regulation: suppressing regulatory T-cell function to treat cancers.

@article{Knutson2006StrongarmingIR,
  title={Strong-arming immune regulation: suppressing regulatory T-cell function to treat cancers.},
  author={Keith L. Knutson},
  journal={Future oncology},
  year={2006},
  volume={2 3},
  pages={379-89}
}
In recent years there has been an accelerated understanding of immune regulatory mechanisms. Much of this immune regulation is linked to a collection of specialized regulatory cells of the T-cell lineage (Tregs). This collection consists of Tregs that are either thymically derived or peripherally induced. Tregs are important for controlling potentially autoreactive immune effectors and immune responses to foreign organisms and molecules. Their importance in maintaining immune homeostasis and… CONTINUE READING