Strong antibody responses induced by protein antigens conjugated onto the surface of lecithin-based nanoparticles.

@article{Sloat2010StrongAR,
  title={Strong antibody responses induced by protein antigens conjugated onto the surface of lecithin-based nanoparticles.},
  author={Brian R. Sloat and Michael A Sandoval and Andrew M. Hau and Yongqun He and Zhengrong Cui},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2010},
  volume={141 1},
  pages={93-100}
}
An accumulation of research over the years has demonstrated the utility of nanoparticles as antigen carriers with adjuvant activity. Herein we defined the adjuvanticity of a novel lecithin-based nanoparticle engineered from emulsions. The nanoparticles were spheres of around 200nm. Model protein antigens, bovine serum albumin (BSA) or Bacillus anthracis protective antigen (PA) protein, were covalently conjugated onto the nanoparticles. Mice immunized with the BSA-conjugated nanoparticles… CONTINUE READING

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