Strong and persistent microbial and inflammatory stimuli overcome the genetic predisposition to higher matrix metalloproteinase-1 (MMP-1) expression: a mechanistic explanation for the lack of association of MMP1-1607 single-nucleotide polymorphism genotypes with MMP-1 expression in chronic periodont

@article{Repeke2009StrongAP,
  title={Strong and persistent microbial and inflammatory stimuli overcome the genetic predisposition to higher matrix metalloproteinase-1 (MMP-1) expression: a mechanistic explanation for the lack of association of MMP1-1607 single-nucleotide polymorphism genotypes with MMP-1 expression in chronic periodont},
  author={Carlos Eduardo Repeke and Ana Paula Favaro Trombone and Samuel Ferreira and Cristina Ribeiro de Barros Cardoso and Elcia Maria Varize Silveira and Walter J{\'u}nior Martins and Paula Cristina Trevilatto and Jo{\~a}o S. Silva and Ana Paula Campanelli and Gustavo Pompermaier Garlet},
  journal={Journal of clinical periodontology},
  year={2009},
  volume={36 9},
  pages={726-38}
}
AIMS Our objective was to evaluate the association between the MMP1-1607 single-nucleotide polymorphism (SNP), periodontopathogens and inflammatory cytokines with matrix metalloproteinase-1 (MMP-1) mRNA levels in vitro and in vivo. MATERIALS AND METHODS This study investigated the influence of genetic (MMP1-1607 SNP), microbial (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Actinobacillus actinomycetemcomitans) and inflammatory [tumour necrosis factor-alpha (TNF-alpha… CONTINUE READING
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Tumor necrosis

  • A. P. Trombone, C. R. Cardoso, +9 authors G. P. Garlet
  • 2008
Highly Influential
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