Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells.

Abstract

Positive selection of functional CD8+ T cells expressing an MHC class I-restricted T cell receptor can be induced in fetal thymus organ culture by class I-binding peptides related to the antigenic peptide ligand. Peptides that act as antagonist or weak agonist/antagonist ligands for mature T cells work efficiently in this regard. In the present study, we… (More)

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