Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease.

@article{Vanhove2015StrongUO,
  title={Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease.},
  author={Wiebe Vanhove and Paul M. J. G. Peeters and Dominiek Staelens and Anica Schraenen and Jan Van der Goten and Isabelle Cleynen and Sebastiaan De Schepper and Leentje van Lommel and Niki L. Reynaert and Frans Schuit and Gert Van Assche and Marc Ferrante and Gert de Hertogh and Emiel F. M. Wouters and P. R. Rutgeerts and S{\'e}verine Vermeire and Kris Nys and Ingrid Arijs},
  journal={Inflammatory bowel diseases},
  year={2015},
  volume={21 11},
  pages={
          2673-82
        }
}
BACKGROUND Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the gut, partly driven by defects in the innate immune system. Considering the central role of inflammasome signaling in innate immunity, we studied inflammasome components in IBD mucosa. METHODS Expression of genes encoding inflammasome sensor subunits was investigated in colonic mucosal biopsies from 2 cohorts of patients with IBD and controls. RESULTS A significant upregulation (>2-fold change in… CONTINUE READING
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