Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein.

@article{Gupta2016StrongSS,
  title={Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein.},
  author={Aditi Gupta and Christoph Adami},
  journal={PLoS genetics},
  year={2016},
  volume={12 3},
  pages={e1005960}
}
Epistatic interactions between residues determine a protein's adaptability and shape its evolutionary trajectory. When a protein experiences a changed environment, it is under strong selection to find a peak in the new fitness landscape. It has been shown that strong selection increases epistatic interactions as well as the ruggedness of the fitness landscape, but little is known about how the epistatic interactions change under selection in the long-term evolution of a protein. Here we analyze… CONTINUE READING
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