Strong RNA splicing enhancers identified by a modified method of cycled selection interact with SR protein.

@article{Tian2001StrongRS,
  title={Strong RNA splicing enhancers identified by a modified method of cycled selection interact with SR protein.},
  author={Huicheng Tian and R. Kole},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 36},
  pages={
          33833-9
        }
}
A modified method of cycled selection was used to characterize splicing enhancers for exon inclusion from a pool of beta-globin-based three exon/two intron pre-mRNAs with a variable number of random nucleotides incorporated in the internal exon. The pre-mRNAs generated by this method contained random sequences ranging from 0 to 18 nucleotides in length. This method was used to isolate particular splicing enhancer motifs from a previously enriched pool of extremely diverse enhancers. After four… CONTINUE READING
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