Strong Ion Gap is Associated With Mortality in Pediatric Burn Injuries

@article{Sen2014StrongIG,
  title={Strong Ion Gap is Associated With Mortality in Pediatric Burn Injuries},
  author={Soman Sen and Arek J Wiktor and Allison E. Berndtson and David G. Greenhalgh and Tina Louise Palmieri},
  journal={Journal of Burn Care \& Research},
  year={2014},
  volume={35},
  pages={337–341}
}
Severe burn injury produces significant tissue damage, resulting in metabolic acidosis. Current methods of acid–base evaluation are based on dependent variables that may not be accurate after burn injury. The strong ion method of acid–base evaluation is based on independent variables and may accurately predict outcomes in severely burn-injured patients. The authors hypothesize that an increased strong ion gap present on admission will be associated with mortality in severely burn-injured… 
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9 Citations

9 Citations

Citation Type

Citation Type

Burn Center Volume Makes a Difference for Burned Children*
TLDR
Higher volume pediatric burn centers had lower mortality, particularly at larger burn sizes, which could reflect greater experience, resource, and specialized expertise in treating pediatric patients.
A comparison of prognostic significance of strong ion gap (SIG) with other acid-base markers in the critically ill: a cohort study
TLDR
The prognostic significance of strong ion gap was modest and inferior to arterial lactate concentration for the critically ill, and lactate concentration should always be considered regardless of physiological, base excess or physical-chemical approach to interpret acid-base disturbances in critically ill patients.
Non-lactate strong ion difference and cardiovascular, cancer and all-cause mortality
TLDR
A high nlSID is associated with an increase in cardiovascular, cancer and all-cause mortality and may be a prognostic indicator of mortality in general adult population.
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Connecting two worlds: positive correlation between physicochemical approach with blood gases and pH in pediatric ICU setting
TLDR
This study revealed the positive correlation between physicochemical parameters and the blood gas pH, serving as a connecting dot for further investigations using physicochemical approach to evaluate acid–base disturbance in pediatric population.
Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock
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Glutamine metabolism contributes to increased succinate concentration in plasma during hemorrhagic shock and the glutaminolytic pathway is implicated as a therapeutic target to prevent the contribution of succinate accumulation in plasma and the lung-to-postshock pathogenesis.
Brecha de iones fuertes y su cinética de aclaramiento como marcador de mortalidad en pacientes con choque séptico
Materiais e métodos: Um estudo retrospectivo, observacional com dados obtidos a partir do prontuário médico. Realizado na UTI de um hospital particular na cidade de Monterrey, em Nuevo León. Foram…
Metabolic Acidosis
Surprisingly High Levels of Strong Ion Gap in Pediatric Burn Patients Study.
  • R. Gatz, Paul Elbers
  • Medicine
    Journal of burn care & research : official publication of the American Burn Association
  • 2016

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TLDR
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