Stromelysin-1 and gelatinase A are upregulated before TNF-alpha in LPS-stimulated neuroinflammation.

@article{MunBryce2002Stromelysin1AG,
  title={Stromelysin-1 and gelatinase A are upregulated before TNF-alpha in LPS-stimulated neuroinflammation.},
  author={Sheila Mun-Bryce and Anton Lukes and James Wallace and Manuela Lukes-Marx and Gary A Rosenberg},
  journal={Brain research},
  year={2002},
  volume={933 1},
  pages={42-9}
}
Neuroinflammation induces a complex molecular cascade that leads to the proteolysis of cells. Matrix metalloproteinases (MMPs) attack all components of the extracellular matrix in a number of neuroinflammatory diseases and cause a delayed opening of the blood-brain barrier (BBB). Earlier, we showed that lipopolysaccharide (LPS) disrupted the BBB through the action of gelatinase B (MMP-9). In a study of cerebral ischemia, gelatinase A (MMP-2) was seen in astrocytic end-feet and stromelysin-1… CONTINUE READING
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