Stromelysin-1 (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase-3 are overexpressed in the wall of abdominal aortic aneurysms.

@article{Carrell2002Stromelysin1M,
  title={Stromelysin-1 (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase-3 are overexpressed in the wall of abdominal aortic aneurysms.},
  author={T. W. G. Carrell and Kevin Guiver Burnand and Graham M A Wells and John M. Clements and Alberto Smith},
  journal={Circulation},
  year={2002},
  volume={105 4},
  pages={477-82}
}
BACKGROUND Atherosclerosis is implicated in the pathogenesis of abdominal aortic aneurysm (AAA) but more often causes aortic occlusive disease (AOD). The matrix metalloproteinases (MMPs) degrade extracellular matrix and may play a central role in the pathogenesis of AAA. The aim of this study was to examine differences in the patterns of MMP and MMP inhibitor expression between AAA and AOD. METHODS AND RESULTS The expression of mRNA for 14 MMPs and 4 tissue inhibitors of metalloproteinases… CONTINUE READING