Stromelysin, gelatinase A and TIMP-1 in prosthetic interface tissue: a role for macrophages in tissue remodelling.

@article{Hembry1995StromelysinGA,
  title={Stromelysin, gelatinase A and TIMP-1 in prosthetic interface tissue: a role for macrophages in tissue remodelling.},
  author={Rosalind M. Hembry and Meena Bagga and J. Joshua Reynolds and David L. Hamblen},
  journal={Histopathology},
  year={1995},
  volume={27 2},
  pages={149-59}
}
Aseptic loosening of prosthetic components is the most important long-term complication of total joint replacement. To investigate the underlying destructive mechanisms, periprosthetic tissues from both well-fixed and loosened sites from six patients, undergoing surgery for aseptic loosening of knee or hip prostheses, were analysed in detail by immunohistochemical methods for the presence of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 (TIMP-1). The tissues contained… CONTINUE READING