Stromal regulation of vessel stability by MMP14 and TGFbeta.

  title={Stromal regulation of vessel stability by MMP14 and TGFbeta.},
  author={Nor Eddine Sounni and Kerstin Dehne and L{\'e}on C van Kempen and Mikala Egeblad and Nesrine I. Affara and Ileana Cuevas and Jane Wiesen and Simon Junankar and Lidiya V Korets and Jake Jungbin Lee and Jennifer Shen and Charlotte J. Morrison and Christopher M. Overall and Stephen M. Krane and Zena Werb and Nancy Boudreau and Lisa M. Coussens},
  journal={Disease models & mechanisms},
  volume={3 5-6},
Innate regulatory networks within organs maintain tissue homeostasis and facilitate rapid responses to damage. We identified a novel pathway regulating vessel stability in tissues that involves matrix metalloproteinase 14 (MMP14) and transforming growth factor beta 1 (TGFbeta(1)). Whereas plasma proteins rapidly extravasate out of vasculature in wild-type mice following acute damage, short-term treatment of mice in vivo with a broad-spectrum metalloproteinase inhibitor, neutralizing antibodies… CONTINUE READING
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