Stromal reengineering to treat pancreas cancer.

  title={Stromal reengineering to treat pancreas cancer.},
  author={Ingunn M. Stromnes and Kathleen E DelGiorno and Philip D. Greenberg and Sunil Hingorani},
  volume={35 7},
Pancreatic ductal adenocarcinoma co-opts multiple cellular and extracellular mechanisms to create a complex cancer organ with an unusual proclivity for metastasis and resistance to therapy. Cell-autonomous events are essential for the initiation and maintenance of pancreatic ductal adenocarcinoma, but recent studies have implicated critical non-cell autonomous processes within the robust desmoplastic stroma that promote disease pathogenesis and resistance. Thus, non-malignant cells and… CONTINUE READING
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