Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function.

@article{Collins2014StromalIM,
  title={Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function.},
  author={Helen E Collins and Lan He and Luyun Zou and Jing Qu and Lufang Zhou and Silvio Litovsky and Qinglin Yang and Martin E. Young and Richard B. Marchase and John C. Chatham},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2014},
  volume={306 8},
  pages={
          H1231-9
        }
}
The endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) has been implicated as a key mediator of store-dependent and store-independent Ca(2+) entry pathways and maintenance of ER structure. STIM1 is present in embryonic, neonatal, and adult cardiomyocytes and has been strongly implicated in hypertrophic signaling; however, the physiological role of STIM1 in the adult heart remains unknown. We, therefore, developed a novel cardiomyocyte-restricted STIM1 knockout ((cr… 

Figures from this paper

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Taken together, the hearts of STIM1 haploinsufficient mice had a superficial resemblance to the WT phenotype under stress-free conditions; however, STIM2 heterozygous KO mice showed a maladaptive response to cardiac pressure overload.

STIM1-dependent Ca2+ microdomains are required for myofilament remodeling and signaling in the heart

It is shown that mice with inducible, cardiac-restricted, ablation of STIM1 exhibited left ventricular reduced contractility, which was corroborated by impaired single cell contractility and showed less adverse structural remodeling in response to pressure overload-induced cardiac hypertrophy, highlighting howSTIM1-dependent Ca2+ microdomains have a major impact on intracellular Ca2+.

STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases

The goal of this review is to describe the current understanding of the molecular regulation of STIM and Orai proteins and their roles in normal physiology and diseases of aging, with a particular focus on heart disease and neurodegeneration.

STIM1 enhances SR Ca2+ content through binding phospholamban in rat ventricular myocytes

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