Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function.

  title={Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function.},
  author={Helen E Collins and Lan He and Luyun Zou and Jing Qu and Lufang Zhou and Silvio Litovsky and Qinglin Yang and Martin E. Young and Richard B. Marchase and John C. Chatham},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={306 8},
The endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) has been implicated as a key mediator of store-dependent and store-independent Ca(2+) entry pathways and maintenance of ER structure. STIM1 is present in embryonic, neonatal, and adult cardiomyocytes and has been strongly implicated in hypertrophic signaling; however, the physiological role of STIM1 in the adult heart remains unknown. We, therefore, developed a novel cardiomyocyte-restricted STIM1 knockout ((cr… 

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