Stromal gene signatures in large-B-cell lymphomas.

  title={Stromal gene signatures in large-B-cell lymphomas.},
  author={Georg Lenz and George Wright and Sandeep S Dave and Wen-zheng Xiao and J Powell and Hai-feng Zhao and Wei-guo Xu and Boon-Yew Tan and Neta Goldschmidt and Javed Iqbal and J Vose and M. Bast and Kunfa Fu and Dennis D. Weisenburger and Timothy C. Greiner and James Olen Armitage and Anna Kyle and Linda May and Randy D. Gascoyne and Joseph M. Connors and Gunhild Troen and Harald Holte and Stein O Kvaloy and Daan Dierickx and G. Verhoef and Jan Delabie and Erlend B Smeland and Pedro Jares and Alejandro Mart{\'i}nez and Armando L{\'o}pez-Guillermo and Emilio Montserrat and Elies Campo and Rita M. Braziel and Thomas P. Miller and Lisa M Rimsza and James R Cook and Betsy Pohlman and J. Sweetenham and Ray R Tubbs and Richard I. Fisher and Ernest Hartmann and Andreas Rosenwald and German Ott and H-K Muller-Hermelink and David Wrench and T. Andrew Lister and Elaine S. Jaffe and Wyndham H. Wilson and Wing Chung Chan and Louis M. Staudt},
  journal={The New England journal of medicine},
  volume={359 22},
BACKGROUND The addition of rituximab to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), or R-CHOP, has significantly improved the survival of patients with diffuse large-B-cell lymphoma. Whether gene-expression signatures correlate with survival after treatment of diffuse large-B-cell lymphoma is unclear. METHODS We profiled gene expression in pretreatment biopsy specimens from 181 patients with diffuse large-B-cell lymphoma who received CHOP… CONTINUE READING
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