Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast.

@article{Ariga2001StromalEO,
  title={Stromal expression of fibroblast activation protein/seprase, a cell membrane serine proteinase and gelatinase, is associated with longer survival in patients with invasive ductal carcinoma of breast.},
  author={Naohiro Ariga and Elichi Sato and Noriaki Ohuchi and Hiroshi Nagura and Haruo Ohtani},
  journal={International journal of cancer},
  year={2001},
  volume={95 1},
  pages={67-72}
}
Fibroblast activation protein (FAP)/seprase is a serine integral membrane proteinase with gelatinase activity, which is expressed by activated fibroblasts in the stroma of various epithelial cancers, mesenchymal tumors and breast-cancer cells, as well as during wound repair. However, the pathophysiologic significance of its expression remains poorly understood. The present study was designed to reveal the impact of stromal expression of FAP/seprase on survival in human breast cancer… CONTINUE READING