Stromal expression of c-Ets1 transcription factor correlates with tumor invasion.

  title={Stromal expression of c-Ets1 transcription factor correlates with tumor invasion.},
  author={Nicolas Wernert and Fr{\'e}d{\'e}ric Gilles and V{\'e}ronique Fafeur and Fatima Bouali and M B Raes and Charles Pyke and Thierry Dupressoir and Gabriele Seitz and Bernard Vandenbunder and Dominique St{\'e}helin},
  journal={Cancer research},
  volume={54 21},
The stroma reaction has an important role in tumor growth, invasion, and metastasis. In various invasive human carcinomas, as well as in a mouse model for tumor invasion, transcripts encoding the transcription factor c-Ets1 were detected within stromal fibroblasts, whereas they were absent in epithelial tumor cells. This expression of c-Ets1 was often increased in fibroblasts directly adjacent to neoplastic cells. Endothelial cells of stromal capillaries were also positive for c-Ets1 expression… CONTINUE READING
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L A c - ets - 1 proto oncoproteinbinding site in the 72 - kDa type IV collagenase promoterof human metastatic melanoma cells

  • G. D. Rosen, T. M. Birkenmeier, D. C. Dean
  • Clin . Exp . Metastasis
  • 1993

Synergistic activation of the H ' FLVl LTR Ets - responsive region by transcription factors Etsi and Spi

  • R. Bosselut, R. A. Bailly, J. Ghysdael
  • EMBO J .
  • 1993

Distributionof basement membranes in primary and metastatic carcinomas of the prostate

  • C. Nathan, M. Spent
  • Hum . Pathol .
  • 1992

Expression patterns of c - myb and of v - myb induced myeloid - 1 ( mim - 1 ) gene during the devel opment of the chick embryo

  • J. M. Chirgwin, A. E. Przybyla, R. J. Mac Donald, W. J. Rutter
  • Development
  • 1992

Identificationof nucleotidepreferences in DNA sequence recognised specifically by c - Ets - 1 protein

  • D. B. Woods, J. Ghysdael, M. J. andOwen
  • Nucleic Acids Res .
  • 1992

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