Stromal expression of c-Ets1 transcription factor correlates with tumor invasion.

@article{Wernert1994StromalEO,
  title={Stromal expression of c-Ets1 transcription factor correlates with tumor invasion.},
  author={Nicolas Wernert and Fr{\'e}d{\'e}ric Gilles and V{\'e}ronique Fafeur and Fatima Bouali and M B Raes and Charles Pyke and Thierry Dupressoir and Gabriele Seitz and Bernard Vandenbunder and Dominique St{\'e}helin},
  journal={Cancer research},
  year={1994},
  volume={54 21},
  pages={5683-8}
}
The stroma reaction has an important role in tumor growth, invasion, and metastasis. In various invasive human carcinomas, as well as in a mouse model for tumor invasion, transcripts encoding the transcription factor c-Ets1 were detected within stromal fibroblasts, whereas they were absent in epithelial tumor cells. This expression of c-Ets1 was often increased in fibroblasts directly adjacent to neoplastic cells. Endothelial cells of stromal capillaries were also positive for c-Ets1 expression… CONTINUE READING
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