Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.

@article{Poulsom1992StromalEO,
  title={Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.},
  author={Richard Poulsom and Massimo Pignatelli and William G Stetler-Stevenson and Lance A. Liotta and Peter A. Wright and Rosemary E. Jeffery and Janet M. Longcroft and L. A. Rogers and Gordon Stamp},
  journal={The American journal of pathology},
  year={1992},
  volume={141 2},
  pages={389-96}
}
We undertook an in situ hybridization study to localize the mRNAs for the 72 kda type IV collagenase (MMP-2) and its specific inhibitor (TIMP-2) in 12 colorectal carcinomas, 3 adenomas, and 4 uninvolved resection margins to see how their distributions correlated with that of the reported distribution of MMP-2 protein. Labeling for MMP-2 and TIMP-2 mRNAs was detectable in 10 of 12 carcinomas and in 2 of 3 adenomas. Unexpectedly, we found much stronger signals for MMP-2 and TIMP-2 mRNAs within… CONTINUE READING