Stromal cells in chronic inflammation and tertiary lymphoid organ formation.

  title={Stromal cells in chronic inflammation and tertiary lymphoid organ formation.},
  author={Christopher D Buckley and Francesca Barone and Saba Nayar and C{\'e}cile B{\'e}n{\'e}zech and Jorge Caama{\~n}o},
  journal={Annual review of immunology},
Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflammatory cells within inflamed tissues. Furthermore, at many sites of chronic inflammation, structures that mimic secondary lymphoid tissues are observed, suggesting that chronic… CONTINUE READING
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