Stromal cells confer lymph node-specific properties by shaping a unique microenvironment influencing local immune responses.

@article{Ahrendt2008StromalCC,
  title={Stromal cells confer lymph node-specific properties by shaping a unique microenvironment influencing local immune responses.},
  author={Manuela Ahrendt and Swantje Iris Hammerschmidt and Oliver Pabst and Reinhard Pabst and Ulrike Bode},
  journal={Journal of immunology},
  year={2008},
  volume={181 3},
  pages={1898-907}
}
Lymph nodes (LN) consist not only of highly motile immune cells coming from the draining area or from the systemic circulation, but also of resident stromal cells building the backbone of the LN. These two cell types form a unique microenvironment which is important for initiating an optimal immune response. The present study asked how the unique microenvironment of the mesenteric lymph node (mLN) is influenced by highly motile cells and/or by the stromal cells. A transplantation model in rats… CONTINUE READING