Stromal-cell regulation of dendritic-cell differentiation and function.

  title={Stromal-cell regulation of dendritic-cell differentiation and function.},
  author={Mattias Svensson and Paul M. Kaye},
  journal={Trends in immunology},
  volume={27 12},
Dendritic cells (DCs) are the ubiquitous sentinels of the immune system, instructing and shaping the adaptive immune response. As such, DCs are often targeted directly by pathogens as a means of immune evasion. Although DCs in different anatomical locations originate from common bone-marrow-derived progenitors and, hence, share several characteristics, microenvironmental factors have an important influence on DC biology under both steady-state and inflammatory conditions. A growing body of… CONTINUE READING

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