Stromal cell-mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling.

@article{Jitschin2015StromalCG,
  title={Stromal cell-mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling.},
  author={Regina Jitschin and Martina Braun and Mirjeta Qorraj and Domenica Saul and Katarina Le Blanc and Thorsten Zenz and Dimitrios Mougiakakos},
  journal={Blood},
  year={2015},
  volume={125 22},
  pages={
          3432-6
        }
}
It is well established that the stromal niche exerts a protective effect on chronic lymphocytic leukemia (CLL) cells, thereby also affecting their drug sensitivity. One hallmark of malignant cells is metabolic reprogramming, which is mostly represented by a glycolytic shift known as the Warburg effect. Because treatment resistance can be linked to metabolic alterations, we investigated whether bone marrow stromal cells impact the bioenergetics of primary CLL cells. In fact, stromal contact led… CONTINUE READING

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Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic BLOOD, 28 MAY 2015 x VOLUME 125, NUMBER 22 STROMA PROMOTES WARBURG EFFECT IN CLL CELLS

R Jitschin, AD Hofmann, H Bruns
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