Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury.

@article{Abbott2004StromalCF,
  title={Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury.},
  author={J Dawn Abbott and Yan Huang and Dingang Liu and Reed Hickey and Diane S Krause and Frank J. Giordano},
  journal={Circulation},
  year={2004},
  volume={110 21},
  pages={
          3300-5
        }
}
BACKGROUND After myocardial infarction (MI), bone marrow-derived cells (BMDCs) are found within the myocardium. The mechanisms determining BMDC recruitment to the heart remain unclear. We investigated the role of stromal cell-derived factor-1alpha (SDF-1) in this process. METHODS AND RESULTS MI produced in mice by coronary ligation induced SDF-1 mRNA and protein expression in the infarct and border zone and decreased serum SDF-1 levels. By quantitative polymerase chain reaction, 48 hours… CONTINUE READING
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