Stromal cell-derived factor-1 and hepatocyte growth factor guide axon projections to the extraocular muscles.

@article{Lerner2010StromalCF,
  title={Stromal cell-derived factor-1 and hepatocyte growth factor guide axon projections to the extraocular muscles.},
  author={O. M. Lerner and Dominic Davenport and Priya C. Patel and Maria Psatha and Ivo Lieberam and Sarah Guthrie},
  journal={Developmental neurobiology},
  year={2010},
  volume={70 8},
  pages={
          549-64
        }
}
Vertebrate eye movements depend on the co-ordinated function of six extraocular muscles that are innervated by the oculomotor, trochlear, and abducens nerves. Here, we show that the diffusible factors, stromal cell-derived factor-1 (SDF-1) and hepatocyte growth factor (HGF), guide the development of these axon projections. SDF-1 is expressed in the mesenchyme around the oculomotor nerve exit point, and oculomotor axons fail to exit the neuroepithelium in mice mutant for the SDF-1 receptor CXCR4… CONTINUE READING

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