Stromal cell-derived factor 1 alpha-induced chemotaxis in T cells is mediated by nitric oxide signaling pathways.

@article{Cherla2001StromalCF,
  title={Stromal cell-derived factor 1 alpha-induced chemotaxis in T cells is mediated by nitric oxide signaling pathways.},
  author={Rama P. Cherla and Ramesh Kumar Ganju},
  journal={Journal of immunology},
  year={2001},
  volume={166 5},
  pages={
          3067-74
        }
}
Stromal cell-derived factor 1 alpha (SDF1 alpha) and its cognate chemokine receptor CXCR4 act as potent chemoattractants and regulate trafficking and homing of hematopoietic progenitor cells and lymphocytes. However, the molecular mechanisms regulating SDF1 alpha-driven cell migration are not well defined. In this study, we have explored the roles of the second messenger NO and the transcription factor NF-kappa B in SDF1 alpha-induced T cell migration. SDF1 alpha treatment of Jurkat T cells… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…