Stromal cell-derived factor-1 (SDF-1) as a target in liver diseases.

@article{Liepelt2016StromalCF,
  title={Stromal cell-derived factor-1 (SDF-1) as a target in liver diseases.},
  author={Anke Liepelt and Frank Tacke},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2016},
  volume={311 2},
  pages={
          G203-9
        }
}
The chemokine stromal cell-derived factor-1 (SDF-1) or CXCL12 is constitutively expressed in healthy liver. However, its expression increases following acute or chronic liver injury. Liver sinusoidal endothelial cells (LSEC), hepatic stellate cells (HSC), and malignant hepatocytes are important sources of SDF-1/CXCL12 in liver diseases. CXCL12 is able to activate two chemokine receptors with different downstream signaling pathways, CXCR4 and CXCR7. CXCR7 expression is relevant on LSEC, while… CONTINUE READING
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