Stromal cell derived factor-1 (SDF-1) targeting reperfusion reduces myocardial infarction in isolated rat hearts.

@article{Jang2012StromalCD,
  title={Stromal cell derived factor-1 (SDF-1) targeting reperfusion reduces myocardial infarction in isolated rat hearts.},
  author={Young-Ho Jang and June H. Kim and Changill Ban and Kyohan Ahn and J Cheong and Hyung Hoi Kim and Jung-Soo Kim and Yong-Hyun Park and Jun Yong Kim and K L Chun and Gyeong-Ho Lee and Miju Kim and CheolMin Kim and Zhelong Xu},
  journal={Cardiovascular therapeutics},
  year={2012},
  volume={30 5},
  pages={264-72}
}
Recent studies have shown that stromal cell derived factor-1 (SDF-1), first known as a cytokine involved in recruiting stem cells into injured organs, confers myocardial protection in myocardial infarction, which is not dependent on stem cell recruitment but related with modulation of ischemia-reperfusion (I/R) injury. However, the effect of SDF has been studied only in a preischemic exposure model, which is not clinically relevant if SDF is to be used as a therapeutic agent. Our study was… CONTINUE READING

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