Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling

  title={Stromal SLIT2 impacts on pancreatic cancer-associated neural remodeling},
  author={V{\'e}ronique Secq and Julie Leca and Christian Bressy and Fabienne Guillaumond and Paulina Skrobuk and J Nigri and Sophie Lac and M-N Lavaut and T-t Bui and Ashish Kumar Thakur and N Callizot and R Steinschneider and Patrice Berth{\'e}z{\`e}ne and Nelson Dusetti and Mehdi Ouaissi and Vincent M Moutardier and E. Calvo and Chlo{\'e} Bousquet and S Hern{\'a}ndez Garc{\'i}a and Ghislain Bidaut and Sophie Vasseur and Juan Iovanna and Richard Tomasini},
  booktitle={Cell Death and Disease},
Pancreatic ductal adenocarcinoma (PDA) is a critical health issue in the field of cancer, with few therapeutic options. Evidence supports an implication of the intratumoral microenvironment (stroma) on PDA progression. However, its contribution to the role of neuroplastic changes within the pathophysiology and clinical course of PDA, through tumor recurrence and neuropathic pain, remains unknown, neglecting a putative, therapeutic window. Here, we report that the intratumoral microenvironment… CONTINUE READING
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