Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis

@article{Pan2006StromalDF,
  title={Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis},
  author={Judong Pan and Javier Mestas and Marie D. Burdick and Roderick J Phillips and George V Thomas and Karen L Reckamp and John A Belperio and Robert M. Strieter},
  journal={Molecular Cancer},
  year={2006},
  volume={5},
  pages={56 - 56}
}
Renal cell carcinoma (RCC) is characterized by organ-specific metastases. The chemokine stromal derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 have been suggested to regulate organ-specific metastasis in various other cancers. On this basis, we hypothesized that the biological axis of CXCL12 via interaction with its receptor, CXCR4, is a major mechanism for RCC metastasis. We demonstrated that CXCR4 was significantly expressed on circulating cytokeratin+ RCC cells from patients with… CONTINUE READING

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