Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases

  title={Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases},
  author={Wladimir Gerstenberger and Michaela Wrage and Eeva Kettunen and Klaus Pantel and Sisko L. Anttila and Stefan Steurer and Harriet Wikman},
  journal={Analytical Cellular Pathology (Amsterdam)},
The expression of caveolin-1 (CAV1) in both tumor cell and cancer-associated fibroblasts (CAFs) has been found to correlate with tumor aggressiveness in different epithelial tumor entities, whereas less is known for caveolin-2 (CAV2). The aim of this study was to investigate the clinicopathological significance and prognostic value of stromal CAV1 and CAV2 expression in lung cancer. The expression of these two genes was investigated at protein level on a tissue microarray (TMA) consisting of… 

Figures and Tables from this paper

Expression of caveolin-2 in patients with oral cancer and correlations with clinicopathological parameters

The expression of CAV2 had relatively high predictive value for the OS and RFS of patients with oral cancer within 5 years after operation, of which the area under curve was 0.827 and 0.874, and the optimal cut-off value was 27.97% and 32.84%, respectively.

Multifaceted Roles of Caveolin-1 in Lung Cancer: A New Investigation Focused on Tumor Occurrence, Development and Therapy

The valuable research on Cav-1 and lung cancer in recent years is summarized and the multifaceted roles of Cav- 1 on lung cancer occurrence, development and therapy are discussed, hoping to provide new insights into lung cancer treatment.

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

It is shown that two particular subsets of cancer associated fibroblasts induce metastasis but work via distinct mechanisms including, chemokine signalling and Notch signalling, which are known to promote the progression of cancer.

High tumor cell platelet‐derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma

PDGFRB and SPARC are suggested as potential markers for risk stratification and as targets for therapy inMalignant pleural mesothelioma and high expression of platelet‐derived growth factor receptor beta in tumor cells is associated with shorter survival.

CAV2 Regulates Mir-4723/Wnt7A Signalling Axis through Endocytosis and Epithelial-Mesenchymal Transition to Promote Proliferation, Invasion, and Metastasis of Pancreatic Cancer Cells

It is demonstrated for the first time that CAV2 exerts a pro-carcinogenic effect on pancreatic cancer through the activation of the Wnt7A/β-catenin signalling pathway.

Caveolin-1 expression predicts favourable outcome and correlates with PDGFRA mutations in gastrointestinal stromal tumours (GISTs)

Caveolin-1 represents a novel prognostic marker in gastrointestinal stromal tumours and is associated with favourable histopathologic and clinical traits, including a lower mitotic count and lower relapse rate.

Caveolae as Potential Hijackable Gates in Cell Communication

Because cell signaling is one of the most dynamic domains in translating data from basic to clinical research, the hypothesis whether these microdomains could serve as hijackable “gatekeepers” or “Gateways” in cell communication is raised.

Tumor-stroma biomechanical crosstalk: a perspective on the role of caveolin-1 in tumor progression

Current knowledge on the several pivotal roles of the essential caveolar component caveolin-1 in this multidirectional biomechanical crosstalk are reviewed and standing questions in the field are highlighted.



Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival.

The loss of stromal CAV-1 expression in CRC was associated with poor prognosis and could be a prognostic factor for CRC patients.

Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival

Caveolins are the principal protein component of caveolae, plasma membrane invaginations found in most cell types. Caveolin-1 (Cav-1) plays a major role in oncogenesis through its various functions

Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma

The current results highlight the prognostic importance of caveolin-1 expression by CAFs in stage I lung adenocarcinoma and provide new insights into the biological significance of caveolae in the tumor microenvironment, especially in microenvironment of solid predominant adenOCarcinomas.

Expression of caveolin-1 is correlated with disease stage and survival in lung adenocarcinomas

The levels of cav-1 mRNA and protein expression were significantly lower in lung cancers when compared to matched TF or non-cancerous lung tissues, and the higher protein expression correlated with the advanced pathological stage and shorter survival rates in lung AC patients.

The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

The loss of stromal caveolin-1 is related to poor prognosis in IDC, and the expression loss is correlated with a shorter disease-free survival and an overall survival.

Stromal cell expression of caveolin-1 predicts outcome in breast cancer.

Stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression and the onset of mammary tumors driven by Her2/neu overexpression was accelerated in mice lacking caveolini-1, thereby supporting the observation that the presence of caveolin1 in the tumor microenvironment modulates tumor development.

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease spread and epithelial Akt activation

Examination of the status of stromal Cav-1 expression in patients with benign prostatic hypertrophy, primary prostate cancers, and prostate-cancer metastases provides important new clinical evidence for paracrine signaling between prostate cancer epithelial cells and the tumorStromal micro-environment, especially related to disease progression and metastasis.

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers.

Stromal Cav-1 expression can be used to stratify human breast cancer patients into low-risk and high-risk groups, and to predict their risk of early disease recurrence at diagnosis, as well as to recommend anti-angiogenic therapy in addition to standard regimens.

Absence of caveolin-1 expression in carcinoma-associated fibroblasts of invasive micropapillary carcinoma of the breast predicts poor patient outcome

Absence of Cav-1 expression in CAFs is a strong prognostic factor for IMPC patients, and it may further subgroup the patients with lymph node metastasis to guide clinical management.

Expression of caveolin-1 is correlated with lung adenocarcinoma proliferation, migration, and invasion

The hypothesis that it regulates lung adenocarcinoma cell proliferation and metastasis via modulation of epidermal growth factor receptor (EGFR) activity is tested and the relationship of CAV-1 with Ki67 expression, a marker of proliferative capacity, in lungAdenocARCinoma samples is suggestive of its role in disease progression.