Stromal Antigen Targeting by a Humanised Monoclonal Antibody: An Early Phase II Trial of Sibrotuzumab in Patients with Metastatic Colorectal Cancer

  title={Stromal Antigen Targeting by a Humanised Monoclonal Antibody: An Early Phase II Trial of Sibrotuzumab in Patients with Metastatic Colorectal Cancer},
  author={R Hofheinz and Salah-Eddin Al-Batran and Frank Hartmann and Gernot Hartung and Dirk J{\"a}ger and Christoph Renner and Paul Tanswell and Ulrich Kunz and Andree Amelsberg and Hartmut Kuthan and Gregor Stehle},
  journal={Oncology Research and Treatment},
  pages={44 - 48}
Background: A novel immunological approach to colon cancer therapy is the antibody targeting of the fibroblast activation protein (FAP), which is highly expressed by stroma cells of this tumour. Unconjugated sibrotuzumab (BIBH 1), which is a humanised version of the murine anti-FAP mAb F19, was investigated for its anti-tumour activity, safety and pharmacokinetics. Patients and Methods: Patients with metastatic colorectal cancer received weekly intravenous infusions of unconjugated sibrotuzumab… 

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