Stroke prevention versus bleeding risk of vitamin-K antagonists: a double-edged sword in patients with atrial fibrillation who require surgery.

@article{Dobrev2009StrokePV,
  title={Stroke prevention versus bleeding risk of vitamin-K antagonists: a double-edged sword in patients with atrial fibrillation who require surgery.},
  author={Dobromir Dobrev and Andreas Goette and Ursula Ravens},
  journal={Cardiovascular therapeutics},
  year={2009},
  volume={27 4},
  pages={223-5}
}
Patients with atrial fibrillation taking vitamin-K antagonists and undergoing invasive interventions or large surgery procedures are at highest risk of bleeding complications. Therefore, the temporary interruption of vitamin-K antagonists and bridging with heparin is a frequent clinical need, particularly in patients with high risk for stroke. The management of such patients is challenging because of the lack of randomized clinical trials assessing different periprocedural anticoagulation… CONTINUE READING