Stroke Neuroprotection: Targeting Mitochondria

  title={Stroke Neuroprotection: Targeting Mitochondria},
  author={Lora Talley Watts and Reginald Lloyd and Richard Justin Garling and Timothy Duong},
  booktitle={Brain sciences},
Stroke is the fourth leading cause of death and the leading cause of long-term disability in the United States. Blood flow deficit results in an expanding infarct core with a time-sensitive peri-infarct penumbra that is considered salvageable and is the primary target for treatment strategies. The only current FDA-approved drug for treating ischemic stroke is recombinant tissue plasminogen activator (rt-PA). However, this treatment is limited to within 4.5 h of stroke onset in a small subset of… CONTINUE READING