Stroke: molecular mechanisms and potential targets for treatment.

  title={Stroke: molecular mechanisms and potential targets for treatment.},
  author={Zhen Chang Zheng and Jacqueline E. Lee and Midori A Yenari},
  journal={Current molecular medicine},
  volume={3 4},
Significant advances have been made over the past few years concerning the cellular and molecular events underlying ischemic cell death. The brain succumbs to ischemic injury as a result of loss of metabolic stores, excessive intracellular calcium accumulation, oxidative stress, and potentiation of the inflammatory response. Neurons can also die via necrotic or apoptotic mechanisms, depending on the nature and severity of the insult. While it has been widely held that ischemia is notable for… CONTINUE READING