Strips of Hope: Accuracy of Home Pregnancy Tests and New Developments.

@article{Gnoth2014StripsOH,
  title={Strips of Hope: Accuracy of Home Pregnancy Tests and New Developments.},
  author={Christian Gnoth and S. Johnson},
  journal={Geburtshilfe und Frauenheilkunde},
  year={2014},
  volume={74 7},
  pages={
          661-669
        }
}
The first home pregnancy test was introduced in 1976. Since then, pregnancy tests have become the most common diagnostic assay used at home. Pregnancy tests use antibodies to detect human chorionic gonadotropin (hCG). It is an ideal marker of pregnancy since it rises rapidly and consistently in early pregnancy and can be detected in urine. The most advanced home pregnancy test currently available assesses the level of hCG found in urine and claims to provide women with reliable results within… Expand
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Comparison of analytical sensitivity and women’s interpretation of home pregnancy tests
TLDR
Many home-based pregnancy tests commonly used by women are not as accurate as their packaging information claims, and international test standards which define appropriate performance characteristics for home pregnancy tests are urgently required. Expand
Analysis of Human Chorionic Gonadotropin Levels in Normal and Failing Pregnancies [40]
TLDR
Urinary hCG profiles in viable pregnancies are consistent but significantly different from those in early losses, making early loss identifiable by hCG trajectory before any clinical symptoms. Expand
Peri‐implantation urinary hormone monitoring distinguishes between types of first‐trimester spontaneous pregnancy loss
TLDR
A wider LH‐hCG interval range is associated with biochemical pregnancy loss and may relate to late or early implantation, although early hCG changes discriminate between pregnancies that will miscarry from viable pregnancies, this point‐of‐care testing model is not sufficiently developed to be predictive. Expand
The home pregnancy test
TLDR
Today's home pregnancy tests provide women the answer to one of the most important questions she may have in a convenient, discrete, and reliable way when well designed, with good usability features, clear instructions, and a robust assay. Expand
Qualitative point-of-care human chorionic gonadotropin testing: can we defuse this ticking time bomb?
TLDR
A search of the FDA's MAUDE database using the search term “MAUDE pregnancy false negative” determined to be false-negative POC hCG results in women found to be pregnant at the time of testing or who were later shown to be pregnancy by ultrasound or quantitative serum hCG measurement. Expand
Analytical sensitivity of four commonly used hCG point of care devices.
TLDR
All hCG POC devices evaluated in this study were susceptible to false negative results at low concentrations of urine hCG, and Laboratorians and clinicians should be aware that there are limitations when using urine h CG Poc devices to rule out early pregnancy. Expand
Pregnancy Reasonably Excluded Guide (PREG) Evaluation of Pregnancy Status Before Contraceptive Procedures: Improved Availability of Same-Day Insertion
TLDR
Whether implementation of the Pregnancy Reasonably Excluded Guide (PREG) in a primary care gynecology clinic improves access to contraceptive procedures and affects the number of urine human chorionic gonadotropin (hCG) tests is investigated. Expand
Evidence-based pregnancy testing in clinical trials: Recommendations from a multi-stakeholder development process
TLDR
Recommendations included: the study protocol should clearly state the rationale for pregnancy testing and the plan for handling positive and indeterminate tests, and the consent process should describe the extent of knowledge about the study intervention’s potential risk to the embryo/fetus and the limitations and consequences of pregnancy testing. Expand
Analysis of urinary human chorionic gonadotrophin concentrations in normal and failing pregnancies using longitudinal, Cox proportional hazards and two-stage modelling
TLDR
Rise of human chorionic gonadotrophin in early pregnancy could be useful to predict pregnancy viability and may enable early identification of some pregnancies at risk of miscarriage. Expand
Preoperative pregnancy testing in surgical patients: How useful is policy of routine testing
TLDR
The cost-effectiveness of POPT appears doubtful, but considering costs associated with miscarriages and medicolegal litigations due to unclear association with anaesthesia, it may indeed be cost-effective. Expand
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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